McNabb has totaled 3,097 yards on 531 carries and 25 touchdowns rushing in his career, along with 362 yards on 63 attempts and three touchdowns in the playoffs.

McNabb holds the record for most consecutive pass attempts completed with 24 over two games in 2004 against the New York Giants (his final 10 passes on November 28, 2004) and Green Bay Packers (his first 14 passes on December 5, 2004).[25] Mark Brunell and David Carr hold the record for most consecutive completed passes in a single game with 22. McNabb also completed 25 consecutive passes against the San Diego Chargers on October 23, 2005, but this record is not counted by the NFL as it included a spiking of the ball to stop the clock at the end of the half. The 2005 game was also noteworthy for Coach Reid calling for McNabb to have 25 pass attempts in a row, without interruption by a running play.

After finishing the 2008 season with career totals of 4303 pass attempts and only ninety interceptions, McNabb is the least intercepted quarterback per pass attempt in NFL history. McNabb passed Neil O'Donnell formerly of the Pittsburgh Steelers. McNabb's career ratio is one interception in every 47.8 pass attempts (2.09%), while O'Donnell was intercepted once every 47.49 pass attempts (2.11%).